4. Genetics of GCA: GWAS

Genetics of rheumatoid arthritis: GWAS and beyond

The study of complex genetics in autoimmune diseases has progressed at a tremendous pace over the last 4 years, as a direct result of the enormous gains made by genome wide association studies (GWAS). Novel genetic findings are continuously being reported alongside the rapid development of genetic technologies, sophisticated statistical analysis, and larger sample collections. It is now becomin...

Population genetics and GWAS: A primer.

This primer provides some background to help non-specialists understand a new theoretical evolutionary genetics study that helps explain why thousands of variants of small effect contribute to complex traits.

Type 2 Diabetes Genetics: Beyond GWAS.

The global epidemic of type 2 diabetes mellitus (T2D) is one of the most challenging problems of the 21(st) century leading cause of and the fifth death worldwide. Substantial evidence suggests that T2D is a multifactorial disease with a strong genetic component. Recent genome-wide association studies (GWAS) have successfully identified and replicated nearly 75 susceptibility loci associated wi...

GCA: A Massively Parallel Model

We had introduced the massively parallel global cellular automata (GCA) model. Parallel algorithms derived from applications can be mapped straight forward onto this model. In this model a cell in the cell field is dynamically connected (access pattern, dynamic neighbourhood) to other cells. The model can be implemented by pointers stored in the cell state. Via these pointers, each cell has rea...

The GCA-w Massively Parallel Model